Tag: paper

Filling in the genetic gaps in the phylogenetic tree of nearby human species!

Filling in the genetic gaps in the phylogenetic tree of nearby human species!

#paper #sequencing #genome #denisovans #neanderthaler

Originally shared by +Nature News & Comment

A new high-coverage DNA sequencing method reconstructs the full genome of Denisovans — relatives to both Neandertals and humans — from genetic fragments in a single finger bone.

New DNA analysis shows ancient humans interbred with Denisovans
A new high-coverage DNA sequencing method reconstructs the full genome of Denisovans — relatives to both Neandertals and humans — from genetic fragments in a single finger bone.

Filling in the genetic gaps in the phylogenetic tree of nearby human species! 

Filling in the genetic gaps in the phylogenetic tree of nearby human species! 

#paper   #sequencing   #genome    #denisovans   #neanderthaler  

Reshared post from +Nature News & Comment

A new high-coverage DNA sequencing method reconstructs the full genome of Denisovans — relatives to both Neandertals and humans — from genetic fragments in a single finger bone.

New DNA analysis shows ancient humans interbred with Denisovans
A new high-coverage DNA sequencing method reconstructs the full genome of Denisovans — relatives to both Neandertals and humans — from genetic fragments in a single finger bone.

With the massive amount of papers and vast amount of data in the pipeline for the…

With the massive amount of papers and vast amount of data in the pipeline for the…

With the massive amount of papers and vast amount of data in the pipeline for the Human Encode project you would almost forget that the same principle (try to apply all molecular assays onto all kind of cell types) is being applied to other species like in Mouse ECODE project. As mouse is one of the laboratories work horses this kind of projects are essential for the advancements in like drug development or in general a better understanding of molecular biology. Will be great to see over the next couple of years how this project is evolving and how much of the results are comparable with the Human. 

http://goo.gl/PxVG0

#paper   #mouseencode   #ENCODE  

Embedded Link

Genome Biology | Full text | An encyclopedia of mouse DNA elements (Mouse ENCODE)
To complement the human Encyclopedia of DNA Elements (ENCODE) project and to enable a broad range of mouse genomics efforts, the Mouse ENCODE Consortium is applying the same experimental pipelines dev…

I think for a paper like this it would be more interesting to see if the amount of mutations with a functional effect (coding or regulatory) is also increasing with age and with what rate this is happening.

I think for a paper like this it would be more interesting to see if the amount of mutations with a functional effect (coding or regulatory) is also increasing with age and with what rate this is happening.

Another great thing would be if they would actually sequence the same person with samples from each a different age and see the actual changes instead of the inferred mutations.

Paper: http://www.nature.com/nature/journal/v488/n7412/full/nature11396.html#/affil-auth
#paper
#genomics #genetics #sequencing #evolution

Originally shared by +Lorna Salgado

"Men in their 20s harbor about 25 random mutations, while a 40-year-old man has 65 mutations on average."

Scientists have found solid evidence that older men have more random mutations in their sperm cells. They're warning that can cause autism, schizophrenia and a long list of other genetic diseases in their offspring.

The new report, in the journal Nature, comes from deCODE Genetics, an Icelandic firm that studied the entire genomes of 78 families involving 219 individuals.

It's not the first time researchers have suggested the father's age is linked to increased genetic risk. The hypothesis goes back nearly a century. But the Icelandic researchers have shown that the father's contribution to genetic disorders is far higher than the mother's.

It makes sense. Men churn out around 200 million sperm a day, providing 200 million daily opportunities for spontaneous "point" mutations when genes get mis-copied. But once women reach puberty, they don't make new egg cells, so their rate of mutations – usually errors in chromosomes, or whole groups of genes – is fixed.

And sure enough, the new paper shows that the rate of new mutations rises steadily in men's germ cells – doubling every 16 1/2 years. Men in their 20s harbor about 25 random mutations, while a 40-year-old man has 65 mutations on average.

Kids Of Older Fathers Likelier To Have Genetic Ailments : NPR
Icelandic scientists have found solid evidence that older men have more random mutations in their sperm cells. They’re warning that can cause autism, schizophrenia and a long list of other genetic dis…

I think for a paper like this it would be more interesting to see if the amount of…

I think for a paper like this it would be more interesting to see if the amount of…

I think for a paper like this it would be more interesting to see if the amount of mutations with a functional effect (coding or regulatory) is also increasing with age and with what rate this is happening. 

Another great thing would be if they would actually sequence the same person with samples from each a different age and see the actual changes instead of the inferred mutations. 

Paper: http://www.nature.com/nature/journal/v488/n7412/full/nature11396.html#/affil-auth
#paper  
#genomics    #genetics   #sequencing   #evolution  

Reshared post from +Lorna Salgado

"Men in their 20s harbor about 25 random mutations, while a 40-year-old man has 65 mutations on average."

Scientists have found solid evidence that older men have more random mutations in their sperm cells. They're warning that can cause autism, schizophrenia and a long list of other genetic diseases in their offspring.

The new report, in the journal Nature, comes from deCODE Genetics, an Icelandic firm that studied the entire genomes of 78 families involving 219 individuals.

It's not the first time researchers have suggested the father's age is linked to increased genetic risk. The hypothesis goes back nearly a century. But the Icelandic researchers have shown that the father's contribution to genetic disorders is far higher than the mother's.
 
It makes sense. Men churn out around 200 million sperm a day, providing 200 million daily opportunities for spontaneous "point" mutations when genes get mis-copied. But once women reach puberty, they don't make new egg cells, so their rate of mutations – usually errors in chromosomes, or whole groups of genes – is fixed.

And sure enough, the new paper shows that the rate of new mutations rises steadily in men's germ cells – doubling every 16 1/2 years. Men in their 20s harbor about 25 random mutations, while a 40-year-old man has 65 mutations on average.

Embedded Link

Kids Of Older Fathers Likelier To Have Genetic Ailments : NPR
Icelandic scientists have found solid evidence that older men have more random mutations in their sperm cells. They’re warning that can cause autism, schizophrenia and a long list of other genetic dis…

How several SNPs determine the effect of your workout

How several SNPs determine the effect of your workout

Interesting find in in the following paper (http://goo.gl/S4FR5) they found out that there are 11 SNPs that can predict how much your VO2max is increased when doing exercise.

The found that these 11 SNPs are capable of explaining 23% of the variance measurable for gain of VO2max for people doing exercise. Soon enough there will be a genetic test available to test yourself (though most SNPs are also in the common +23andMe genotypes, so if you're a bit geeky you can find out yourself with this more common commercial genotype service!).

For the people in the UK (or people with a UK VPN) the BBC spent some time on this topic in the latest Horizon. They also showed new types of exercise that can help you getting the health benefits of sporting in a fraction of the time you'd spent right now (like 3 minutes per week!), which sounds really similar to Tabata workouts.

#GWAS #personalgenomics #paper

Embedded Link

Horizon: 2011-2012: The Truth About Exercise

Horizon: 2011-2012: The Truth About Exercise
Uncovering research that has the power to make us all live longer and healthier lives.

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